Antiproliferative and Apoptotic Effects of Vanadyl Sulphate on H-Ras Transformed 5rp7 Cells

Metal based drugs have successfully been used in the detection and treatment of a variety of diseases [1]. Despite the advantages in early diagnostic and treatment of cancer, there is essential to develop new alternative of drugs. A number of in vitro studies have revealed that vanadium shows its antitumor effects on various cell lines [2]. Moreover, it is shown that vanadium compounds may show cytotoxic effects through DNA cleavage and fragmentation, in vitro [3]. According to these studies, here in we aimed to investigate the cytotoxic and antiproliferative effect of vanadyl sulphate in vitro, also to detect the effect of this agent on H-Ras transformed 5RP7 cells ultrastructure.